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Table 1 Comparison of viral proteins ORF 3 and M of hCoV-NL63 and SARS-CoVa

From: Human Coronavirus NL63 Open Reading Frame 3 encodes a virion-incorporated N-glycosylated membrane protein

Viral protein hCoV-NL63 ORF 3 SARS-CoV ORF 3a hCoV-NL63 M SARS-CoV M
No. amino acids [size in kDa] 225 [26] 274 [31] 226 [26] 221 [25]
No. transmembrane domains (position) 3 (39-61, 70-92, 97-116) 3 (34-56, 77-99,103-125) 4 (20-38, 43-65, 75-97, 129-151) 3 (15-37, 50-72, 77-99)
No. cysteine residues (position) 4 (72, 131, 137, 182) 8 (81, 117, 121, 127, 130, 133, 148, 157) 4 (54, 67, 90, 180) 3 (158, 63, 85)
No. putative N-glycosylation sites (position) 3 (16, 119, 126) 1 (227b) 3 (3, 19, 188) 1 (4c)
No. putative O-glycosylation sites (position) - 3 (28c, 32c, 267-271) - -
  1. aPositions of aa refer to accession no. NC_005831 (hCoV-NL63) and AY278491 (SARS-CoV)
  2. bNot used
  3. cUsage confirmed