Groups of orthologous genes in A46 and related families. (A) Phylogenetic relationships among the orthologue groups obtained from A46, N1, N2 and C1 families. A Bayesian phylogenetic tree was constructed from a multiple sequence alignment of proteins encoded by genes in the ten orthologue groups. For simplicity only a representative species of every poxvirus genus, as depicted in (B), was selected. Posterior probabilities of every node are shown. (B) Virus genomes representing genera Orthopoxvirus (VACV-COP), Leporipoxvirus (MYXV-LAU), Capripoxvirus (LSDV-NW_LW), Suipoxvirus (SWPV-NEB), Yatapoxvirus (YLDV-Davis) and Cervidpoxvirus (DPV-W848_83) are depicted, indicating the relative genome positions of genes included in the orthologue groups. Species/strain names as in Figure 1A; VACV-COP, vaccinia virus strain Copenhagen. Numbers above every line represent the gene positions in the genome. Symbols below every line represent gene names. Genes drawn in the same colour belong to the same orthologue group.