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Table 2 Inhibition of the enzyme activity of the A(H1N1) isolates in Yamagata in the NA inhibition assay

From: A two-year survey of the oseltamivir-resistant influenza A(H1N1) virus in Yamagata, Japan and the clinical effectiveness of oseltamivir and zanamivir

Viruses Amino Acid at position 275
in the NA gene
IC50 values in the NA inhibition assay (nM)
   Oseltamivir Zanamivir
2007-2008 isolates    
   A/Yamagata/1/2008 Histidine 0.08 0.52
   A/Yamagata/66/2008 Tyrosine 50.16 0.45
   A/Yamagata/67/2008 Histidine 0.03 0.22
   A/Yamagata/68/2008 Tyrosine 39.71 0.55
   A/Yamagata/69/2008 Histidine 0.17 0.78
2008-2009 isolates    
   A/Yamagata/126/2008 Tyrosine 59.04 0.50
   A/Yamagata/128/2008 Tyrosine 47.59 0.40