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Table 4 Mutations detected in centrally located genes.

From: Molecular characterisation of virulence graded field isolates of myxoma virus

Gene

 

M009

M010

M011

M017

M036

  

nt

aa

nt

aa

nt

aa

nt

aa

nt

aa

Strain a

A

87

        

T39162

FS5

          

T38822C

K144E

          

G38274

FS7

 

466

        

TTT39162

K31

          

T38822C

K144E

 

2012

        

TTT39162

K31

          

T38822C

K144E

 

86

        

T 39162

FS5

          

T38822C

K144E

          

G38274

FS7

B

2788

  

C13481T

A55T

T13898C

 

TT18008

FS3

T38822C

K144E

    

C13423T

S74N

      
 

7514

G12955A

T59M

      

TTT39162

K31

          

T38822C

K144E

 

1312

AT12172

FS1

      

TT39162

FS6

          

T38822C

K144E

          

Δ G38274

FS8

          

A37515G

 

C

7411

G13021A

S37L

    

Δ T18008

FS4

G39097A

A52V

          

C38616T

 

E

4604

C12818G

A105V

  

T13898C

 

TT18008

FS3

T39162

FS5

          

T38822C

K144E

          

G37215A

 
 

6918

Δ 10nt (11939-11948)

FS2

      

C37687

FS9

          

C37733T

A507T

          

T38701C

D184G

  

C12293A

G280C

      

G38996A

R86W

  1. , insertion; nt, nucleotide residue; aa, amino acid residue; FS, frame shift; * indicates STOP codon.
  2. FS1, ORF changes from 323YVV... to 323YTS*; FS2, frame shift after aa 395 [8]; FS3, 29KRNRSVNN... to 29KKEIEV*; FS4, 29KRNRSVNN... to 29KEIEV*; FS5, 29KKHVSAILEFGF... to 29KKTCKRHFRIRVS*; FS6, 29KKHVSAILEFGF... to 29KKNM*; FS7, 325PPKLGESVSRKQSC... to 325PPQTGGIGEPKAIV*; FS8, 325PPKLGESVSRKQSC... to 325PPNWGNR*; FS9, frame shift after aa 446 [8]. aStrain virulence grade and identification number are indicated. Virulence grades being equivalent to the grades I-V previously designated by Fenner and Marshall [10].