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Table 3 Mutations detected in TIR genesa.

From: Molecular characterisation of virulence graded field isolates of myxoma virus

Gene

M002

M004(f)

M004.1

M005(f)

M007

Strainb

nt

aa

nt

aa

nt

aa

nt

aa

nt

aa

A

87

    

A4750G

F46L

C4937T

A483T

T8394C

Q128R

      

G4754A

     
 

466

  

G4457C

N60K

  

C4937T

A483T

  
 

2012

  

G4457C

N60K

  

C4937T

A483T

  
 

86

    

A4750G

F46L

C4937T

A483T

  
      

G4754A

     

B

2788

C 2600

FS

  

G4715A

   

T8394C

Q128R

 

7514

          
 

1312

C2219T

D143N

  

G4775A

   

T8394C

Q128R

          

G8456T

 

C

7411

G2393A

R85W

C4412T

       

E

4604

          
 

6918

C2594T

G18S

      

G8064A

S238F

  

G2497A

S50F

        
  1. , insertion; nt, nucleotide residue; aa, amino acid residue; FS, predicted M002L ORF frame shift (16GGGAPYGADRGKCRGNDYEKD... to 16GGRCPVWRGSRKM*); * indicates STOP codon.(f) gene fragment.
  2. aFor clarity only the coordinates of changes occurring in the L-TIR genes are indicated. nt positions refer to the MV Lu genome (GenBank accession number AF170726).
  3. b Strain virulence grade and identification number are indicated. Virulence grades being equivalent to the grades I-V previously designated by Fenner and Marshall [10].