Figure 3
Identification of EV71 fragments inducing cross immunity to human brain tissue by immunohistochemical staining. Left panel was adult human cerebra and the right panel was human fetus medulla. The naive mice sera was used as negative control (a & b). The serum of immunized mice with peptide of P646-755 was one of the four strong cross immunity peptides(c & d). P2072-2193 was one of the ten weak cross immunity peptides (e & f). P140-249 was one of the five no cross immunity peptides (g & h). The serum of immunized mice with heat inactivated virus was used as positive control (i & j). The staining sites were denoted with arrows (×200).