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Table 1 Fold-increase in transgene expression when comparing A549 cells infected with Ad5 trivalent relative to Ad5 monovalent formulations.

From: Characterization of transgene expression in adenoviral vector-based HIV-1 vaccine candidates

  Protein fold increase (95% CI)a mRNA fold increase (95% CI)b
gag 1.5 (± 0.3) 1.5 (± 0.2)
pol 1.0 (± 0.1) 2.2 (± 0.2)
nef 1.7 (± 0.1) 1.6 (± 0.1)
  1. a Average (n = 2 independent experiments) and 95% Confidence Interval (95% CI) of gag, pol and nef protein fold increases determined by parallel line analysis on the full dose response curves.
  2. b Average (n = 3 independent experiments) and 95% Confidence Interval (95% CI) of RNA fold increases determined by parallel line analysis in the MOI ranges 25 -- 200 for gag and 12-100 for nef and pol.