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Table 3 Summary of variable sites in the glycoprotein E2 between CSFV vaccine strains and representative group 2 strains

From: Antigenic analysis of classical swine fever virus E2 glycoprotein using pig antibodies identifies residues contributing to antigenic variation of the vaccine C-strain and group 2 strains circulating in China

CSFV vaccine strains and representative group 2 strainsa

Antigenic unitb

    

Antigenic unit B/C

Overlapping region

Antigenic unit A/D

Strain

Country

Subgroup

GenBank accession no.

692

705

706

709

713

723

725

729

736

738

745

777

779

780

788

789

847

854

860

863

C-strain

China

1.1

HM175885

A

D

E

L

G

N

D

N

S

V

T

N

S

T

R

S

D

M

T

N

LOM

Korea

1.1

EU789580

A

N

E

L

G

N

D

N

I

V

T

N

S

T

G

F

D

M

T

N

GPE

Japan

1.1

D49533

A

N

E

L

G

N

D

N

I

V

T

N

S

T

G

F

D

M

T

N

Riems

Germany

1.1

AY259122

A

D

E

L

G

N

D

N

S

V

T

N

S

T

R

S

D

M

T

N

LPC

China

1.1

AY526732

A

D

E

L

G

T

D

N

T

V

T

N

S

T

G

F

D

M

T

N

GXBB1

China

2.1

AY450272

T

N

E

P

E

N

G

D

T

T

I

S

V

I

G

F

E

V

I

E

83-s106

China

2.1

AY526727

S

N

E

P

E

N

G

D

I

I

T

S

A

I

G

F

E

V

I

E

Paderborn

Germany

2.1

AY027673

S

N

E

P

E

N

G

D

I

T

T

S

A

I

G

F

E

V

I

E

GXNN1

China

2.1

AY450278

S

N

E

P

E

N

G

D

I

T

T

T

V

I

G

F

E

V

I

G

HZ2-04

China

2.1

EF683609

S

N

E

P

E

S

G

D

I

T

I

S

A

I

G

F

E

V

I

K

HZ-05

China

2.1

EF683629

S

N

E

P

E

S

G

D

I

T

I

R

A

I

G

F

E

V

M

K

HZ1-06

China

2.1

EF683626

S

N

E

P

E

S

G

D

I

T

I

S

A

I

G

F

E

V

I

K

QZ1-06

China

2.1

EF683618

S

N

E

P

E

S

G

D

I

T

I

S

A

I

G

F

E

V

I

K

QZ2-06

China

2.1

EF683619

S

N

E

P

E

S

G

D

I

T

I

S

A

I

G

F

E

V

I

K

HZ1-07

China

2.1

EF683627

S

N

E

P

E

S

G

D

I

T

M

S

A

I

G

F

E

V

I

K

QZ-07

China

2.1

FJ456876

S

N

E

P

E

N

G

D

I

T

I

S

A

I

G

F

E

V

V

K

HZ1-08

China

2.1

FJ582642

S

N

K

P

E

S

G

D

I

T

I

S

A

I

G

F

E

V

I

K

GXWZ02

China

2.1

AY367767

S

N

E

P

E

N

G

D

I

T

I

S

A

I

G

F

E

A

I

K

GX-HP3

China

2.1

AY450276

S

N

E

P

E

N

G

D

I

T

I

S

A

I

G

F

E

V

I

E

GS-ZY

China

2.1

AY450276

S

D

E

L

E

N

G

D

I

T

T

S

A

I

G

F

E

V

I

K

GS-HY

China

2.2

AF143086

A

N

E

L

E

S

D

D

A

I

T

S

V

I

G

F

E

V

M

K

HuB-39

China

2.2

AF407339

A

D

E

L

E

S

G

N

I

I

T

S

V

I

G

F

E

V

M

K

Mathura

India

2.2

EU567077

A

D

G

L

E

S

G

N

I

I

T

S

V

T

G

F

E

V

M

K

84-KS1

China

2.2

AY526729

A

N

E

L

E

S

G

D

I

I

T

S

V

I

G

F

E

V

M

K

LN1.84

China

2.2

DQ907717

A

N

E

L

E

G

G

D

I

I

T

S

V

I

G

F

E

V

M

K

Sukohario

Indonesia

2.2

EU180068

A

N

E

L

E

S

G

D

I

T

T

S

V

I

G

F

E

V

M

K

Roesrath

Germany

2.3

GU233734

A

N

E

L

E

S

D

D

V

T

T

N

V

I

G

F

D

V

I

K

Sp01

Spain

2.3

FJ265020

A

N

E

L

E

S

G

D

V

T

T

N

A

I

G

F

D

V

I

E

Alfor/T

Germany

2.3

J04358

A

N

E

L

E

S

G

D

V

T

T

N

A

I

G

F

D

V

I

K

Uelzen

Germany

2.3

GU324242

A

N

E

L

E

S

S

D

V

T

T

N

A

I

G

F

D

V

I

K

Substitutions based on C-strain rE2 protein by site-directed mutagenesis in this study

A→S

D→N

E→K

L→P

G→E

N→S

D→G

N→D

S→I

V→T

T→I

N→S

S→A

T→I

R→G

S→F

D→E

M→V

T→I

N→K

Enhancement of variant C-strain rE2 proteins in binding to the pig anti-QZ-07 serumc

-

++

-

++

++

++

+

+

-

-

-

+

++

+

-

-

+

+

+

+

  1. aThe five subgroup 1.1 strains listed in this table are the vaccine strains used in different countries. Twenty five representative group 2 strains are listed.
  2. bLocations are derived from the polyprotein of classical swine fever virus C-strain (GenBank accession no. HM175885).
  3. cValues represent binding efficiency of anti-QZ-07 serum to each of variant C-strain rE2 proteins: "++"= changes in binding of greater than 200% compared to that of wild type rE2 protein of C-strain; "+"= changes ranging from 150% to 200%; "-"= changes between 50% and 150%.
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