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Table 5 Amino acid composition of hydrophilic and hydrophobic amino acids in rapid responders (15 variants) and in breakthrough responders (BT)

From: Mutations in the E2-PePHD region of hepatitis C virus genotype-3a and correlation with response to interferon and ribavirin combination therapy in Pakistani patients

 

Hydropathic composition

PePHD

Hydrophobic

Neutral

Hydrophillic

RR group (15 variants)

Leu (L) 16.67

Thr (T) 16.11

Arg (R) 8.89

 

Ile (I) 0.00

Glu (E) 8.33

Lys (K) 0.00

 

Phe (F) 0.00

Gly (G) 0.00

Asn (N) 0.00

 

Trp (W) 0.00

Ser (S) 16.67

His (H) 13.33

 

Val (V) 0.00

Gln (Q) 11.11

Pro (P) 8.33

 

Met (M) 0.00

Asp (D) 0.00

 
 

Cys (C) 0.00

  
 

Tyr (Y) 0.00

  
 

Ala (A) 0.56

  

Average composition

17.23

52.22

30.55

BT group

Leu (L) 22.02

Thr (T) 16.67

Arg (R) 8.33

 

Ile (I) 0.00

Glu (E) 8.33

Lys (K) 0.00

 

Phe (F) 0.00

Gly (G) 0.00

Asn (N) 0.00

 

Trp (W) 0.00

Ser (S) 16.67

His (H) 16.67

 

Val (V) 0.00

Gln (Q) 2.98

Pro (P) 8.33

 

Met (M) 0.00

Asp (D) 0.00

 
 

Cys (C) 0.00

  
 

Tyr (Y) 0.00

  
 

Ala (A) 0.00

  

Average composition

22.02

44.65

33.33