Figure 1

Alignment of deduced amino acid sequence of chCypA homology from different species. A, Amino acid residues aligned by the CLUSTALW program. The residues that match the consensus exactly were shown with ".", the Cyp-type peptidyl-prolyl cis-trans isomerase signatures and the well conserved CsA binding sites were shadowed; the amino acids necessary for the peptidylprolyl cis-trans isomerase activity were marked with"*"; thirteen CsA binding residues were boxed. B, Homology identity between chCypA and other species cyclophilin A. GenBank accession numbers are: P62937 (human), P62940 (rhesus monkey), P17742 (mouse), P62935 (cattle), P14832 (baker's yeast).