Figure 1

Crystallographic structure of RT indicating Selected Regions. (a) RT crystallographic structure 2ZD1 (1.8 Å) highlights the residues within the selected regions, Dark gray = p66 subunit, light gray = p55, dark blue = active site residues involved in dNTP binding (K65, R72, D110, V111, G112, D113, A114, Y115, Q151), green = active site residues involved in DNA binding (L74, V75, D76, R78, N81, E89, Q91, L92, I94, G152, K154, P157, M230, G231), purple = active site residues with no specific annotations (W24, P25, F61), pink = YMDD motif (Y183, M184, D185, D186), and light blue = residues involved in NNRTI binding (L100, K101, K102, K103, V179, Y188, G190, F227; not conserved). Ribbon shows continuity between amino acid chains.