Table 3 Measures of performance of commercially available NS1 detection-based dengue diagnostic assays
Assay | Dengue samples | Non-dengue samples | Positive tests | Negative tests | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | LR+ (95% CI) | LR- (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
Platelia™ | 212 | 91 | 150 | 84 | 70.8 | 92.3 | 95.5 | 57.5 | 9.2 | 0.31 |
(64.1-76.8) | (84.8-96.9) | (91-98.2) | (49.1-65.7) | (4.5-18.8) | (0.25-0.39) | |||||
PanE™ | 218 | 92 | 155 | 82 | 71.1 | 89.1 | 94 | 56.6 | 6.54 | 0.32 |
(64.6-77) | (80.9-94.7) | (89.1-97.1) | (48.1-64.8) | (3.62-11.8) | (0.26-0.4) | |||||
ELISA SD™ | 218 | 92 | 150 | 87 | 68.8 | 94.6 | 96.8 | 56.1 | 12.7 | 0.33 |
(62.2-75) | (87.8-98.2) | (92.6-99) | (48-64.1) | (5.37-29.8) | (0.27-0.4) | |||||
SD Bioline™ | 218 | 92 | 111 | 89 | 51 | 96.7 | 97.4 | 45.4 | 15.6 | 0.5 |
NS1 only | (44.1-57.7) | (90.8-99.3) | (92.5-99.5) | (38.3-52.7) | (5.1-48) | (0.44-0.58) | ||||
SD Bioline™ | 218 | 92 | 171 | 84 | 78.4 | 91.3 | 95.5 | 64.1 | 9.02 | 0.23 |
NS1/IgM | (72.4-83.7) | (83.6-96.2) | (91.4-98.1) | (55.3-72.3) | (4.64-17.6) | (0.18-0.3) | ||||
SD Bioline™ | 218 | 92 | 176 | 82 | 80.7 | 89.1 | 94.6 | 66.1 | 7.43 | 0.21 |
NS1/IgM/IgG | (75-85.7) | (81-94.7) | (90.3-97.4) | (57.1-74.4) | (4.12-13.8) | (0.16-0.28) | ||||
STRIP™ | 104 | 43 | 60 | 41 | 57.7 | 95.3 | 96.8 | 48.2 | 12.4 | 0.44 |
15 min | (47.6-67.3) | (84.2-99.4) | (88.8-99.6) | (37.3-59.3) | (3.17-48.5) | (0.35-0.56) | ||||
STRIP™ | 104 | 43 | 64 | 41 | 61.5 | 93.3 | 97 | 50.6 | 13.2 | 0.4 |
30 min | (51.5-70.9) | (84.2-99.4) | (89.5-99.6) | (39.3-62) | (3.4-51.6) | (0.31-0.5) |