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Table 3 Measures of performance of commercially available NS1 detection-based dengue diagnostic assays

From: Comparison of the diagnostic accuracy of commercial NS1-based diagnostic tests for early dengue infection

Assay Dengue
samples
Non-dengue
samples
Positive
tests
Negative
tests
Sensitivity %
(95% CI)
Specificity %
(95% CI)
PPV %
(95% CI)
NPV %
(95% CI)
LR+
(95% CI)
LR-
(95% CI)
Platelia™ 212 91 150 84 70.8 92.3 95.5 57.5 9.2 0.31
      (64.1-76.8) (84.8-96.9) (91-98.2) (49.1-65.7) (4.5-18.8) (0.25-0.39)
PanE™ 218 92 155 82 71.1 89.1 94 56.6 6.54 0.32
      (64.6-77) (80.9-94.7) (89.1-97.1) (48.1-64.8) (3.62-11.8) (0.26-0.4)
ELISA SD™ 218 92 150 87 68.8 94.6 96.8 56.1 12.7 0.33
      (62.2-75) (87.8-98.2) (92.6-99) (48-64.1) (5.37-29.8) (0.27-0.4)
SD Bioline™ 218 92 111 89 51 96.7 97.4 45.4 15.6 0.5
NS1 only      (44.1-57.7) (90.8-99.3) (92.5-99.5) (38.3-52.7) (5.1-48) (0.44-0.58)
SD Bioline™ 218 92 171 84 78.4 91.3 95.5 64.1 9.02 0.23
NS1/IgM      (72.4-83.7) (83.6-96.2) (91.4-98.1) (55.3-72.3) (4.64-17.6) (0.18-0.3)
SD Bioline™ 218 92 176 82 80.7 89.1 94.6 66.1 7.43 0.21
NS1/IgM/IgG      (75-85.7) (81-94.7) (90.3-97.4) (57.1-74.4) (4.12-13.8) (0.16-0.28)
STRIP™ 104 43 60 41 57.7 95.3 96.8 48.2 12.4 0.44
15 min      (47.6-67.3) (84.2-99.4) (88.8-99.6) (37.3-59.3) (3.17-48.5) (0.35-0.56)
STRIP™ 104 43 64 41 61.5 93.3 97 50.6 13.2 0.4
30 min      (51.5-70.9) (84.2-99.4) (89.5-99.6) (39.3-62) (3.4-51.6) (0.31-0.5)
  1. PPV = Positive Predictive Value, NPV = Negative Predictive Value, LR = Likelihood Ratio