| T4 and Related Phage | T7 Phage | E. coli | Eukaryotes |
---|---|---|---|---|
Replicative DNA polymerase | gp43 polymerase (pdb 1ig9, 1clq, 1noy, 1ih7) | Gene 5 Polymerase (pdb 1t7p, 1skr, 1t8e, 1x9m) | Pol III (αεθ) (pdb 2hnh, 1ido) | Pol δ (subunits p125, p50, p66, p12) (pdb 3e0j) |
Sliding clamp | gp45 protein (pdb 1czd, 1b8h) | E. coli Thioredoxin (pdb 1t7p, 1skr) | β (pdb 2pol) | PCNA (pdb 1plr, 1axc, 1ul1) |
Clamp loader | gp44/62 protein |  | γ complex (γδδ'ψχ) (pdb 1jr3, 1jqj, 3glf) | RF-C (subunits p140, p40, p38, p37, p36) (pdb 1sxj) |
ssDNA binding protein | gp32 protein (pdb 1gpc) | Gene 2.5 protein (pdb 1je5) | SSB (pdb 1qvc) | RP-A (subunits p14, p32, p70) (pdb 1fgu, 2b29, 1jmc, 1l1o, 2pi2) |
Replicative helicase | gp41 helicase | Gene 4 helicase (pdb 1e0j, 1e0k, 1q57) | DnaB (pdb 1b79, 2r6a) | MCM (pdb 3f9v, 1ltl) |
helicase assembly protein | gp59 protein (pdb 1c1k) | Â | DnaC, PriA (pdb 3ec2) | Â |
primase | gp61 primase | Gene 4 primase (pdb 1nui, 1q57) | DnaG (pdb 1dd9, 3b39, 2r6c) | Pol α/primase (pdb 3flo) |
5' to 3' Exonuclease | RNase H (pdb 1tfr, 2ihn) | Â | Pol I N-domain | FEN-1, RNase H1 (pdb 1ul1, 2qk9) |
DNA ligase 1 | T4 ligase (gp30) | T7 ligase (pdb 1a0i) | DNA ligase (pdb 2owo) | DNA ligase I |