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Figure 2 | Virology Journal

Figure 2

From: Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives

Figure 2

Two modes of recombination-dependent replication (RDR) . During semi-conservative RDR, primase action on the displaced strand of the D-loop allows lagging strand synthesis (panel A). In bubble-migration synthesis, lagging strand synthesis does not occur, and the newly synthesized single strand is extruded from the back of the D-loop as new DNA is synthesized at the front of the D-loop (panel B). In this and subsequent figures, new leading strand replication is in solid red and new lagging strand replication is in dashed red; the two starting molecules are differentiated by the green versus black colors.

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