Figure 1

Observed BRLF1 sequence variations in EBVaGC, NPC biopsies and TWs of healthy donors in Northern China. The numbers in the first row correspond to the amino acid positions and the numbers in the second correspond to the nucleotide positions, under which the B95-8 prototype amino acid and nucleotide sequences are listed. Different patterns are noted to the far left column, while the specimens showing identical sequences to each other are listed by a representative isolate in the second column. The following numbers separated by "/" denote the number of the identical sequences from EBVaGC, NPC and TW, respectively. Only sequences different from B95-8 are indicated. The small letters denote the nucleotide, and the amino acids are denoted by capital letters. The GD1 sequence was taken from EBV genomes AY961628 [25]. C666-1 and SNU-719 were two EBV-positive cell lines [26, 27], whose sequences were obtained by using PCR-direct sequencing method.