Figure 2From: Evolution of Dengue Virus Type 3 Genotype III in Venezuela: Diversification, Rates and Population DynamicsAlignment of E protein ectodomain amino acid sequences from DENV-3 genotype III strains isolated in Venezuela. Strains are listed by their names on the left side of the figure, and the cluster to which the strain is assigned is indicated between parentheses (see also Fig. 1). Only one strain of each cluster is shown (for detailed results of substitutions found in the rest of the Venezuelan strains see Additional File 2, Table S2). Identity to strain FJ639750 (DENV-3/VE/BID-V2179/2000) is indicated by a dash. Amino acid positions (relative to strain FJ639750) are shown by numbers at the top of the alignment. Sequences corresponding to E protein domains I, II and III are shown in red, yellow and light blue, respectively. Surface-exposed sequences previously identified on the dimeric DENV-3 protein are shown by a black diamond. Potential ELK/KLE-type and KELK/KLEK-type motifs are shown by a star. Asparagine at position 388 is shown by a white circle. Amino acid residues recently identified to be critical for neutralization by complex-reactive monoclonal antibodies (Mabs) on domain III of DENV-3 are indicated by a black circle [43].Back to article page