Skip to main content
Figure 4 | Virology Journal

Figure 4

From: Functional dissection of the alphavirus capsid protease: sequence requirements for activity

Figure 4

Molecular modelling of the catalytic triad of ChikV capsid protease. (A) Wt catalytic triad in native enzyme with isoleucine at 227. (B) The catalytic triad in mutant enzyme with lysine at 227. The side chain of lysine 227 is very close to side chains of the catalytic triad that will disrupt the electrostatic interactions of catalytic triad. The distance between OD1 of aspartic acid 161 and NZ of lysine 227 is 3.38 Å, which is the optimal distance to form a salt bridge between these residues.

Back to article page