Inflammatory responses to acute pneumovirus infection in neonatal mice

Table 2 Differential inflammatory responses.

Age at Inoculation	1 wk	2 wks	3 wks	4 wks
Group I: Differential responses vary minimally with age at inoculation
CCL1 (TCA-3)	1.2	1.4	2.1	1.6
CCL6 (C10)	1.5	1.7	0.9	2.0
CXCL11 (I-Tac)	1.1	0.6	1.0	0.9
CXCL12	1.0	1.5	0.9	0.7
Group II: Differential responses increase with age at inoculation
CCL2 (MCP-1)^a	0.6	0.1	1.5	1.9
CCL3 (MIP-1α)^a	1.9	2.2	9.8	9.2
CCL4 (MIP-1β)	1.3	1.5	9.8	11.3
CCL5 (RANTES)	1.8	2.9	3.5	4.9
CCL7 (MCP-3)	1.1	1.2	5.8	7.5
CCL8 (MCP-2)	2.2	4.4	1.4	12.1
CCL9 (MIP-1γ)	1.3	1.5	1.4	4.9
CCL11 (eotaxin)	1.9	1.1	2.3	4.3
CCL12 (MCP-5)	1.0	1.9	0.9	3.7
CCL17 (TARC)	1.2	0.9	1.0	14.9
CCL19 (MIP-3β)	2.1	0.9	1.3	29.9
CCL24 (eotaxin 2)	0.8	1.7	0.9	2.1
CXCL-1 (KC)^a	1.4	1.4	0.7	6.5
CXCL9 (MIG)^a	2.5	1.6	78.8	84.4
CXCL10 (IP-10)^a	2.2	2.1	36.8	45.3
CXCL13	1.3	1.8	1.3	7.0
TNF	1.7	1.4	4.6	2.2
IFNγ^a	1.6	1.9	18.4	26.0

Expression of proinflammatory mediators detected by PCR array analysis of RNA from lung tissue of infected mice vs. RNA from lung tissue from age-matched uninfected controls; t = day 7 after inoculation. Ages of mice at time of inoculation are as indicated; ^acorresponding immunoreactive protein shown in Figure 1.

ISSN: 1743-422X