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Table 1 Anti-influeza virus effects of AK extracts and AK fractions by simultaneous treatment assay.

From: In Vitro inhibitory activity of Alpinia katsumadai extracts against influenza virus infection and hemagglutination

Extract or Compound

CC50 (μ g/mL)a

A/PR/8/34 (H1N1)

A/Chicken/Korea/MS96/96 (H9N2)

  

EC50 ( μ g/mL)b

SIc

EC50 ( μ g/mL)b

SIc

Tamiflu

>200

<1.5

>133.3

3.5 ± 1.4

57.1

EtOH extract (AK-1)

27.1 ± 0.4

2.6 ± 1.2

10.4

0.6 ± 1.5

45.2

EtOAc fraction (AK-2)

8.9 ± 2.3

3.3 ± 2.3

2.3

1.2 ± 1.9

7.4

H2O fraction (AK-3)

21.8 ± 4.2

0.8 ± 1.4

27.3

< 0.39 ± 0.4

>55.9

40% methanol fraction (AK-5)

>200

2.0 ± 3.2

>100

2.1 ± 2.3

> 95.2

H2O extract (AK-9)

92.3 ± 4.6

-

-

1.4 ± 0.6

65.9

Polysaccharide fraction (AK-10)

163.5 ± 5.3

12.5 ± 1.1

13.1

2.3 ± 3.6

71.1

Supernatant fraction (AK-11)

119.1 ± 2.4

16.4 ± 4.5

7.3

1.6 ± 0.8

9.3

  1. aCC50 : mean (50%) value of cytotoxic concentration.
  2. bEC50 : mean (50%) value of effective concentration.
  3. cSI: selective index, CC50/EC50.