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Table 1 BaTS results for the extent of clustering of selected mutations in the phylogeny.

From: All that glitters is not gold - founder effects complicate associations of flu mutations to disease severity

Statistic

Mutation

Index Ratio, observed to expected (95% CI)

Observed Value (95% CI)

Expected Value (95% CI)

P-value

AI

HA-D239G

0.74 (0.50-1.11)

2.75 (2.22-3.26)

3.70 (2.95-4.46)

0.03

AI

HA-D239N

0.63 (0.29-1.37)

0.79 (0.49-1.07)

1.25 (0.78-1.67)

0.06

AI

HA-K2E

0.07 (0.05-0.10)

0.39 (0.34-0.46)

5.30 (4.40-6.21)

0

AI

PB2-K340N

0.03 (0-0.04)

0.31 (0.05-0.41)

11.28 (9.87-12.67)

0

AI

HA-Q310H

0.07 (0.01-0.17)

0.31 (0.06-0.64)

4.71 (3.81-5.60)

0

PS

HA-D239G

0.95 (0.94-1)

17 (17-17)

17.87 (17-18)

0.07

PS

HA-D239N

0.84 (0.83-0.83)

5 (5-5)

5.99 (5.99-6)

0.01

PS

HA-K2E

0.12 (0.12-0.12)

3 (3-3)

25.72 (24.87-26)

0

PS

PB2-K340N

0.07 (0.07-0.07)

4 (4-4)

56.51 (54.60-57.87)

0

PS

HA-Q310H

0.18 (0.17-0.18)

4 (4-4)

22.79 (22-23)

0

MC

HA-D239G

NA

2 (2-2)

1.12 (1-2)

0.06

MC

HA-D239N

NA

2 (2-2)

1.01 (1-1.01)

0.01

MC

HA-K2E

NA

24 (24-24)

1.25 (1-2)

0

MC

PB2-K340N

NA

17.32 (17-18)

1.82 (1.12-2.23)

0

MC

HA-Q310H

NA

6.54 (4-11)

1.20 (1-2)

0