Table 1 The homing endonucleases of phage T4
Endonuclease | Intron encoded or free-standing | Active | Family | Insertion Site | Target Gene | Reference |
|---|---|---|---|---|---|---|
I-TevI | Intron | Yes | GIY-YIG | td | td | |
I-TevII | Intron | Yes | GIY-YIG | nrdD | nrdD | [7] |
I-TevIII | Intron | Yes (RB3) | HNH | nrdB | nrdB | |
mobA | Free-standing | ND | HNH | 60.1/39 | 39 | D. Shub pers. comm.. |
mobB | Free-standing | ND | HNH | α-gt/α-gt.2 | unknown |  |
mobC | Free-standing | ND | HNH | nrdG/nrdD | unknown | Â |
mobD | Free-standing | ND | HNH | nrdC.11/mobD.1 | unknown | Â |
mobE | Free-standing | Yes | HNH | nrdB/nrdA | nrdB | |
segA | Free-standing | Yes | GIY-YIG | uvsX/β-gt | uvsX | [34] |
segB | Free-standing | Yes | GIY-YIG | tRNA-Arg/tRNA-Ile | tRNA intergenic region | [38] |
segC | Free-standing | Yes | GIY-YIG | 5.1/5.3 | of 5.1 and 5.3 | [37] |
segD | Free-standing | ND | GIY-YIG | 23/24 | unknown | Â |
segE | Free-standing | Yes | GIY-YIG | inh/uvsW | uvsW | [36] |
segF | Free-standing | Yes | GIY-YIG | soc/56 | 56 | [35] |
segG | Free-standing | Yes | GIY-YIG | 32/59 | 32 | [39] |