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Table 5 Herpes viruses and clinical parameters in pediatric lymphoma patients

From: Presence of Human Herpes Virus 6 (HHV6) in pediatric lymphomas: impact on clinical course and association with cytomegalovirus infection

Factor HHV6 n(%) CMV n(%) Both n(%) Negative n(%) p value
Fever n = 22 3(14) 3(14) 7(32) 9(40) 0.100
Rash n = 9 0(0) 1(11) 2(22) 6(67) 0.479
Organomegaly n = 13 2(15) 1(8) 2(15) 8(62) 0.526
Med. mass n = 18 2(11) 4(22) 2(11) 10(56) 0.869
Mucositis n = 10 2(20) 1(10) 7(70) 0(0) < 0.001
Other infection n = 14 3(21) 0(0) 8(58) 3(21) 0.004
Duration of FN (n = 28)      
Low Risk (< 10 d) n = 15 1(7) 3(20) 2(13) 9(60) 0.136
High Risk (≥ 10 d) n = 13 2(15) 0(0) 7(54) 4(31)  
ANC (Median = 0.8)      
Mild(≥ 0.8)n = 25 3(12) 6(24) 1(4) 15(60) 0.570
Severe (< 0.8)n = 25 3(12) 1(4) 9(36) 12(48)  
Plt count      
≥96 n = 25 4(16) 5(20) 2(8) 14(56) 1.000
< 96 n = 25 2(8) 2(8) 8(32) 13(52)  
Hb      
≥ 9.1 n = 25 3(12) 5(20) 1(4) 16(64) 0.256
< 9.1 n = 25 3(12) 2(8) 9(36) 11(44)  
Mono      
≥ 0.4 n = 25 3(12) 5(20) 2(8) 15(60) 0.570
< 0.4 n = 25 3(12) 2(8) 8(32) 12(48)  
Lymph      
≥ 0.5 n = 25 3(12) 4(16) 1(4) 17(68) 0.089
< 0.5 n = 25 3(12) 3(12) 9(36) 10(40)  
  1. Med. Mass: Mediastinal mass, FN: Febrile neutropenia, ANC: absolute neutrophil count, Plt: Platelet count, Hb: hemoglobin concentration, Mono: monocyte, Lymph: Lymphocyte, HHV6: herpes virus 6 single infection, CMV: cytomegalovirus single infection, Both: positive for HHV6/CMV DNA, Negative: negative for herpes viruses