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Table 4 Relation between demographic and disease characteristics and distribution of herpes viruses among pediatric lymphoma patients

From: Presence of Human Herpes Virus 6 (HHV6) in pediatric lymphomas: impact on clinical course and association with cytomegalovirus infection

Factor

HHV6 n(%)

CMV n(%)

Both n(%)

Negative n(%)

p value

Age

     

< 9 y n = 25

3(12)

3(12)

7(28)

12(48)

0.395

≥9 Y n = 25

3(12)

4(16)

3(12)

15(60)

 

Sex

     

M: n = 32

3(9)

4(13)

7(22)

18(56)

0.670

F: n = 18

3(17)

3(17)

3(17)

9(50)

 

Stage

     

I+II (n = 25)

3(12)

5(20)

4(16)

13(52)

1.000

III+IV (n = 25)

4(16)

3(12)

5(20)

13(52)

 

Phase of therapy

     

Induction: n = 24

2(8)

6(25)

5(21)

11(46)

 

Maintenance: n = 23

3(13)

1(4)

3(13)

16(70)

0.034

Salvage: n = 3

1(33)

0(0)

2(67)

0(0)

 

Status of disease

     

CR+PR: n = 42

5(12)

6(14)

6(14)

25(60)

0.021

SD+PD: n = 8

2(25)

1(13)

4(50)

1 (13)

 

Outcome

     

Af: n = 38

4(11)

6(16)

6(16)

22(59)

 

Ad: n = 10

1(10)

0(0)

4(40)

5(50)

*

D: n = 2

1(50)

1(50)

0(0)

0(0)

 
  1. CR: Complete remission, PR: Partial remission, SD: Stationary disease, PD: Prolonged disease, Af: Alive free of disease, Ad: Alive with disease, D: Died, HHV6: herpes virus 6 single infection, CMV: cytomegalovirus single infection, Both: positive for HHV6/CMV DNA, Negative: negative for herpes viruses
  2. * No p value because only two patients died.