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Table 4 Relation between demographic and disease characteristics and distribution of herpes viruses among pediatric lymphoma patients

From: Presence of Human Herpes Virus 6 (HHV6) in pediatric lymphomas: impact on clinical course and association with cytomegalovirus infection

Factor HHV6 n(%) CMV n(%) Both n(%) Negative n(%) p value
Age      
< 9 y n = 25 3(12) 3(12) 7(28) 12(48) 0.395
≥9 Y n = 25 3(12) 4(16) 3(12) 15(60)  
Sex      
M: n = 32 3(9) 4(13) 7(22) 18(56) 0.670
F: n = 18 3(17) 3(17) 3(17) 9(50)  
Stage      
I+II (n = 25) 3(12) 5(20) 4(16) 13(52) 1.000
III+IV (n = 25) 4(16) 3(12) 5(20) 13(52)  
Phase of therapy      
Induction: n = 24 2(8) 6(25) 5(21) 11(46)  
Maintenance: n = 23 3(13) 1(4) 3(13) 16(70) 0.034
Salvage: n = 3 1(33) 0(0) 2(67) 0(0)  
Status of disease      
CR+PR: n = 42 5(12) 6(14) 6(14) 25(60) 0.021
SD+PD: n = 8 2(25) 1(13) 4(50) 1 (13)  
Outcome      
Af: n = 38 4(11) 6(16) 6(16) 22(59)  
Ad: n = 10 1(10) 0(0) 4(40) 5(50) *
D: n = 2 1(50) 1(50) 0(0) 0(0)  
  1. CR: Complete remission, PR: Partial remission, SD: Stationary disease, PD: Prolonged disease, Af: Alive free of disease, Ad: Alive with disease, D: Died, HHV6: herpes virus 6 single infection, CMV: cytomegalovirus single infection, Both: positive for HHV6/CMV DNA, Negative: negative for herpes viruses
  2. * No p value because only two patients died.