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Table 3 Association of HIV-1 co-receptor usage with the net charge of V3 loop

From: Co-receptor usage and prediction of v3 genotyping algorithms in hiv-1 subtype b' from paid blood donors experienced anti-retroviral therapy in chinese central province

Characteristic

Distributionband frequencycof net charge of V3 loop

Groups

tropism

Na

Mean ± Std

2(%)

3(%)

4(%)

5(%)

6(%)

7(%)

Drug-naïve

R5

66

3.91 ± 1.05

3(3.7)

22(27.2)

25(37.9)

12(18.2)

2(3.0)

2(3.0)

 

X4/R5

15

4.53 ± 0.74

0

 

9(60.0)

4(26. 7)

2(13.3)

0

ART

R5

20

3.75 ± 1.21

1(5.0)

7(35.0)

7(35.0)

3(15.0)

2(10.0)

0

 

X4/R5

22

4.86 ± 1.25

1(4.6)

3(13.6)

5(22.7)

4(18.2)

7(31.8)

2(9.1)

  1. Note: a: the number of cases;
  2. b:it is the net charge of V3 loop according to the formula (V3 net charge=(R+K)-(D+E));
  3. c:it is the frequency of b in the a.
  4. bold: No. of net charge of V3 for R5-tropic viruses distributed mainly below 4, occupied more than 70%;
  5. bold and italic: No. of net charge of V3 for X4-tropic viruses distributed mainly above 4 in drug-naïve group, above 5 in ART group, occupied more than 60%