| Immunogen |  | |||||||
---|---|---|---|---|---|---|---|---|---|
 | Z+GPC VLP | Z+GPC+NP VLP |  | ||||||
ELISA Ag | naive | pre- 1st boost | pre- 2nd boost | term. | naive | pre- 1st boost | pre- 2nd boost | term. | p value |
VLP | 18 ± 17 | 556 ± 975 | 2667 ± 1058 | 12800 ± 14311 | 50 ± 0 | 9920 ± 4637 | 19520 ± 16963 | 32000 ± 20239 | 0.026 |
sGP1 | < 10 | 88 ± 69 | 200 ± 254 | 444 ± 384 ** | < 10 | 1520 ± 1159 | 2480 ± 1159 | 6800 ± 5215 | 0.004 |
GPCΔTM | < 10 | 95 ± 72 | 215 ± 217 | 700 ± 992 * | < 10 | 2960 ± 3657 | 3440 ± 3478 | 10400 ± 15179 | 0.092 |
NP |  |  |  |  | < 10 | 560 ± 310 | 1220 ± 1060 | 2000 ± 1265 |  |