Figure 2

ICAM-1 receptor blocking antibodies abolish the formation of dsRNA replication centers by major group HRVs and CVA21. HeLa cells were pre-incubated with anti-ICAM-1 mab15.2L for 30 min and infected with indicated HRV and CV serotypes. Infection was quantified by the mabJ2 anti-dsRNA antibody using automated image acquisition and analysis. Fold infections relative to untreated control cells are indicated in arbitrary units (AU). The means including standard errors of the mean (SEM) from four independent infections are shown. Example images for HRV1A (A, B) and HRV16 (C, D) are shown, scale bar 25 μm.