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Table 5 Concordance of results of HC-II assay and PCR test for detection of HPV infection in oral squamous cell carcinoma (OSCC): a malignant oral lesionsa

From: Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma

Hybrid Capture-II (HC-II)

HPV-16 E6 PCR

Total

 

HPV-16 E6 Positive

HPV-16 E6 Negative

 

HC-II Positive

61 (84.72%)

11 (15.28%)

72 (100)

HC-II Negative

09 (6.00%)

141 (94.00%)

150 (100)

Total

70

152

222

  1. aCohen's Kappa (λ) = 79.29 (95%CI 0.7067-0.8792); Sensitivity = 87.14% (95% CI: 0.7699-0.9395); Specificity = 92.76% (95% CI: 0.8742-0.9633); Pearson χ2 p < 0.00.