Analyte | Sham-infected | PICV-infected | P-valueb |
---|
ALB (g/dL)
|
5.2 ± 0.2
|
4.0 ± 0.3
|
***
|
ALP (U/L)
c
|
180 ± 27
|
> 1914 ± 606
|
***
|
ALT (U/L)
d
|
160 ± 74
|
> 1894 ± 213
|
***
|
AMY (U/L)
|
1659 ± 408
|
690 ± 227
|
***
|
TBIL (mg/dL) | 0.23 ± 0.05 | 0.62 ± 0.61 | NS |
BUN (mg/dL) | 25.8 ± 1.7 | 24.2 ± 13.4 | NS |
Ca
++
(mg/dL)
|
14.2 ± 0.6
|
13.2 ± 0.8
|
*
|
PHOS (mg/dL)
|
10.6 ± 0.6
|
8.2 ± 1.0
|
***
|
CRE (mg/dL)
e
|
< 0.25 ± 0.05
|
< 0.38 ± 0.12
|
*
|
GLU (mg/dL)
|
183 ± 30
|
80 ± 37
|
***
|
Na+ (mM) | 148 ± 4 | 149 ± 4 | NS |
K+ (mM)f | > 8.5 ± 0.0 | > 8.4 ± 0.1 | NS |
TP (g/dL) | 6.3 ± 0.1 | 6.3 ± 0.4 | NS |
GLOB (g/dL)
|
1.1 ± 0.3
|
2.3 ± 0.5
|
***
|
- aSham-infected, n = 6; PICV-infected, n = 10.
- bStudent's two-tailed t-test. *P < 0.05, **P < 0.01, ***P < 0.001; NS, not significant.
- cThree PICV-infected hamsters had saturated levels of ALP (> 2400 U/L).
- dSeven PICV-infected hamsters had saturated levels of ALT (> 2400 U/L).
- eOne PICV- and three sham-infected hamsters had levels below the limit of detection (0.2 mg/dL)
- fSeven PICV- and six sham-infected hamsters had saturated levels of K+ (8.5 mM).
- Bold font indicates analytes differing significantly between sham- and PICV-infected hamsters.
- ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AMY, amylase; TBIL, total bilirubin; BUN, blood urea nitrogen; Ca++, calcium; PHOS, phosphate; CRE, creatinine; GLU, glucose; Na+, sodium; K+, potassium; TP, total protein; GLOB, globulin.