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Table 4 Clinical and behavioral observations in virus-infected ferrets.

From: Ferrets develop fatal influenza after inhaling small particle aerosols of highly pathogenic avian influenza virus A/Vietnam/1203/2004 (H5N1)

Sign/Observation Range of day(s) symptoms observed postinoculation with virusa
   WS/05
intranasal
IRAQ/06
intranasal
Viet/04
intranasal
Viet/04
aerosol
Deathb N/Oc N/O Days 5 - 12 Days 3 - 5
Soft stool/diarrhea N/O N/O Days 3 - 5 Days 2 - 5
Fever Days 2 - 7 Days 2 - 7 Days 2 - 9 Days 2 - 5
Inappetence Days 2 - 7 Days 4 - 7 Days 3 - 12 Days 2 - 5
Labored breathingd/wheezing Days 4 - 6 N/O Day 5 Days 4 - 5
Lethargy Days 3 - 7 Days 4 - 5 Days 3 - 12 Days 1 - 5
Neurologic signs Aggression-dementia N/O N/O N/O Day 4
  Ataxia N/O N/O Days 5 - 12 Days 4 - 5
  Convulsions N/O N/O Day 5 Days 4 - 5
  Head-tilt N/O N/O N/O Day 4
  Hind-limb paralysis N/O N/O N/O Day 4
  Shaking of head (only) N/O N/O Days 11- 12 N/O
Shaking (whole body) or shivering Days 5 - 6 N/O N/O Days 2 - 4
Sneezing Days 5 - 6 N/O N/O Day 2
Weight loss Days 1 - 7 Days 4 - 7 Days 2 - 12 Days 1 - 5
Resolution Day 8 onwards Day 8 onwards Uncertain N/O
Dehydration/Thin Day 7 N/O Days 5-12 Days 3-5
  1. aTen-day observation period for MO/05 and IRAQ/06; twelve-day for Viet/04.
  2. bAnimals found dead or euthanized for humanitarian reasons
  3. cN/O; not observed.
  4. dLabored breathing; animals exhibited open-mouth breathing with exaggerated abdominal movement.