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Table 3 Outcomes of exposure of ferrets to aerosolized VN/04.

From: Ferrets develop fatal influenza after inhaling small particle aerosols of highly pathogenic avian influenza virus A/Vietnam/1203/2004 (H5N1)

Presented dosea
(TCID50 units/ferret)
Ferret weight and temperature Inactivity indexe Neurologic signs and related observations Lethalityj Virus titerk Isolation of H5N1 from anal swab specimens on indicated day postinfection
  Max. wt. lossb(%) Wt. at term.c(%) Max. T increased(°C)     Nasal washes on indicated day postinfection   
        day 3 day 5 day 3 day 5
3.2 × 101 -11.17 -11.17 1.7 2 None observed 12(e) 2 1 + +
  -16.91 -16.91 0.6 4 Unresponsive (moribund) 5(e) 3 4 + +
  -25.95 -25.95 1.9 4 Ataxiaf
Convulsionsg
Hyper-responsivness to tactile stimulus
5(e) 2 4 + +
3.4 × 102 -20.56 -20.56 1.3 2 Ataxia
Convulsions
Aggression-dementiah
4(e) 2 NA + NA
  -8.44 -8.44 1.7 3 NA 3(d) NA NA NA NA
3.4 × 103 -22.59 -22.59 2.1 4 Ataxia;
Hind-limb paralysis;
Aggression-dementia
4(e) 3 NA + NA
  -17.31 -17.31 1.6 3 Ataxia; Convulsions 4(e) 4 NA + NA
3.4 × 104 -17.21 -17.21 1.5 2 Ataxia; Convulsions
Head tilti
4(d) 4 NA + NA
  -19.40 -19.40 2.0 3 Ataxia; Head tilt 4(e) 3 NA + NA
  1. aBased on TCID50 in Mv1-Lu cells.
  2. bMax. wt., Maximum weight compared to body weight at day 0.
  3. cWt. at term., Weight at termination compared to body weight at day 0.
  4. dCompared to baseline temperature.
  5. eHighest inactivity index value in one observation prior to death or euthanasia.
  6. fAtaxia; incoordination and unsteadiness.
  7. gConvulsions; involuntary muscular contractions.
  8. hAggression-dementia; excessively aggressive biting and snapping of jaws at shadows, inanimate objects including cage walls, and at caretakers.
  9. iHead tilt (torticollis).
  10. jDay ferret found dead (d) or day euthanized (e) for humanitarian reasons.
  11. kValues expressed as log10 TCID50/mL of virus titers using Mv1 Lu cells.