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Figure 1 | Virology Journal

Figure 1

From: Substitution of adeno-associated virus Rep protein binding and nicking sites with human Chromosome 19 sequences

Figure 1

Structure of the wild-type AAV2 and modified ITR. (A) The AAV2 ITR is composed of seven regions, a, a', b, b', c, c' and d, and forms an extensive secondary structure. The b, b', c and c' regions exist in two configurations, "flip" and "flop." The wild type ITR is shown in the flip configuration. (B) A modified version of the ITR, in which the a, a' and d regions are replaced with AAVS1 DNA, was designed in the flop configuration.

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Virology Journal

ISSN: 1743-422X