Table 1 Overlapping prediction of siRNA target sites found within HBV PRE by different bioinformatics tools.

siExplorer

1324-1343

CAUCGGAACUGACAAUUCU

42.1

- 73% match ARP6 actin-related protein 6 homolog transcript¹

- 79% match chromosome x genomiccontig²

T

T

C

T

[40]

1640-1659

UGCCCAAGGUCUUACAUAA

42.1

- 74% match DIX domain containing 1 transcript¹

- 100% match chromosome X genomic contig²

C

T

T

A

1641-1660

GCCCAAGGUCUUACAUAAG

47.3

- 73% match DIX domain containing 1 transcript¹

- 95% match chromosome X genomic contig²

C

C

A

G

siDirect

1344-1366

TCGTCCTCTCGCGGAAATATACA

52

- 66% match oligophrenin 1 (OPHN1) transcript¹

- 71% chromosome 16 open reading frame 35²

G

C

G

A

[41]

siRNA target designer

GTCCTCTCGCGGAAATATA

47

- 73% match oligophrenin 1 (OPHN1) transcript¹

- 74% match hypothetical protein LOC728975²

C

C

A

A

[42]

1321-1339

GCTCATCGGAACTGACAAT

47

- 74% ma₁tch tetraspanin 7 (TSPAN7) transcript¹

- 84% match chromosome 13 contig²

T

A

T

T

Reynolds

et al (2004)

1317-1337*

AAAGCTCATCGGAACTGACAA

42

- 66% match tetraspanin 7 (TSPAN7) transcript¹

- 81% match chromosome 2 genomic contig²

A

C

A

C

[22]

1318-1338

AAGCTCATCGGAACTGACAAT

42

- 66% match tetraspanin 7 (TSPAN7) transcript¹

- 95% match chromosome 17 genomic contig²

G

G

A

A

1329-1349*

AACTGACAATTCTGTCGTCCT

42

- 76% match zinc finger protein 559 (ZNF559) transcript¹

- 76% match chromosome 19 genomic contig²

C

T

T

C

1336-1356

AATTCTGTCGTCCTCTCGCGG

52

- 71% match F-box and leucine-rich repeat protein 15 transcript¹

- 81% match chromosome 20 genomic contig²

T

G

C

C

1357-1377

AAATATACATCGTTTCCATGG

33

- 62% match ADAM metallopeptidase domain 12 (ADAM12) transcript¹

- 76% match chromosome 11 genomic contig²

A

T

T

T

1358-1378

AATATACATCGTTTCCATGGC

42

- 67% match bactericidal/permeability increasing protein-like 2 (BPIL2)¹

- 76% match chromosome 11 genomic contig²

T

C

T

G