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Table 3 Inter-strain nucleotide and amino acid variability of influenza A NS1 complete gene and the three functional gene domains of H1N1v isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics.

From: Genetic divergence of influenza A NS1 gene in pandemic 2009 H1N1 isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics

Mean % nucleotide identity
Strains group comparison Complete Gene Gene Domains
   RNA binding domain (nt 1-219) Effector domain (nt 220-621) Disordered tail (nt 622-657/690)
H1N1 vs H3N2 87.7 84.8 89.5 84.6
H1N1 vs H1N1v 78.8 77.6 80.6 64.7
H3N2 vs H1N1v 77.9 74.9 79.1 80.5
Mean % amino acid identity
Strains group comparison Complete gene Gene Domains
   RNA binding domain (aa 1-73) Effector domain (aa 74-207) Disordered tail (aa 208-219/230)
H1N1 vs H3N2 84.0 82.8 86.2 67.2
H1N1 vs H1N1v 78.9 86.1 78.5 41.7
H3N2 vs H1N1v 77.6 81.5 76.5 66.2