Table 3 Inter-strain nucleotide and amino acid variability of influenza A NS1 complete gene and the three functional gene domains of H1N1v isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics.
Mean % nucleotide identity | ||||
|---|---|---|---|---|
Strains group comparison | Complete Gene | Gene Domains | ||
| Â | Â | RNA binding domain (nt 1-219) | Effector domain (nt 220-621) | Disordered tail (nt 622-657/690) |
H1N1 vs H3N2 | 87.7 | 84.8 | 89.5 | 84.6 |
H1N1 vs H1N1v | 78.8 | 77.6 | 80.6 | 64.7 |
H3N2 vs H1N1v | 77.9 | 74.9 | 79.1 | 80.5 |
Mean % amino acid identity | ||||
Strains group comparison | Complete gene | Gene Domains | ||
| Â | Â | RNA binding domain (aa 1-73) | Effector domain (aa 74-207) | Disordered tail (aa 208-219/230) |
H1N1 vs H3N2 | 84.0 | 82.8 | 86.2 | 67.2 |
H1N1 vs H1N1v | 78.9 | 86.1 | 78.5 | 41.7 |
H3N2 vs H1N1v | 77.6 | 81.5 | 76.5 | 66.2 |