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Table 2 Intra-strain nucleotide and amino acid variability of influenza A NS1 complete gene and the three functional gene domains of H1N1v isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics.

From: Genetic divergence of influenza A NS1 gene in pandemic 2009 H1N1 isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics

   Mean % nucleotide identity (range)
Influenza Strain Max nucleotide substitution Complete Gene Gene Domains
    RNA binding domain (nt 1-219) Effector domain (nt 220-621) Disordered tail (nt 622-657/690)
H1N1 16 98.9 (97.6-100) 99.0 (97.2-100) 98.8 (97.2-100) 99.1 (97.0-100)
H3N2 13 99.4 (98.1-100) 99.1 (96.3-100) 99.6 (98.2-100) 99.0 (95.5-100)
H1N1v 4 99.8 (99.4-100) 99.8 (99.1-100) 99.7 (99.3-100) 99.9 (99.9-100)
  Mean % amino acid identity (range)
Influenza Strain Max amino acid substitution Complete Gene Gene Domains
    RNA binding domain (aa 1-73) Effector domain (aa 74-207) Disordered tail (aa 208-219/230)
H1N1 6 98.6 (96.9-100) 99.6 (97.2-100) 98.2(96.3-100) 97.3(90.9-100)
H3N2 8 98.9 (96.0-100) 98.7 (91.4-100) 99.3 (96.9-100) 97.4 (86.0-100)
H1N1v 4 99.5 (98.6-100) 99.7 (97.2-100) 99.4 (97.7-100) 100