Table 2 Intra-strain nucleotide and amino acid variability of influenza A NS1 complete gene and the three functional gene domains of H1N1v isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics.
| Â | Â | Mean % nucleotide identity (range) | |||
|---|---|---|---|---|---|
Influenza Strain | Max nucleotide substitution | Complete Gene | Gene Domains | ||
| Â | Â | Â | RNA binding domain (nt 1-219) | Effector domain (nt 220-621) | Disordered tail (nt 622-657/690) |
H1N1 | 16 | 98.9 (97.6-100) | 99.0 (97.2-100) | 98.8 (97.2-100) | 99.1 (97.0-100) |
H3N2 | 13 | 99.4 (98.1-100) | 99.1 (96.3-100) | 99.6 (98.2-100) | 99.0 (95.5-100) |
H1N1v | 4 | 99.8 (99.4-100) | 99.8 (99.1-100) | 99.7 (99.3-100) | 99.9 (99.9-100) |
| Â | Mean % amino acid identity (range) | ||||
Influenza Strain | Max amino acid substitution | Complete Gene | Gene Domains | ||
| Â | Â | Â | RNA binding domain (aa 1-73) | Effector domain (aa 74-207) | Disordered tail (aa 208-219/230) |
H1N1 | 6 | 98.6 (96.9-100) | 99.6 (97.2-100) | 98.2(96.3-100) | 97.3(90.9-100) |
H3N2 | 8 | 98.9 (96.0-100) | 98.7 (91.4-100) | 99.3 (96.9-100) | 97.4 (86.0-100) |
H1N1v | 4 | 99.5 (98.6-100) | 99.7 (97.2-100) | 99.4 (97.7-100) | 100 |