A single dose of DNA vaccine based on conserved H5N1 subtype proteins provides protection against lethal H5N1 challenge in mice pre-exposed to H1N1 influenza virus

Table 3 Specific Ab titers in unexposed and pre-exposed mice after immunization^§

^§Mice were grouped and treated as described in Table 2. Three days after the lethal H5N1 challenge, six mice from each subgroup were sacrificed for specific IgG Ab detection by ELISA. NP and M1 proteins obtained by prokaryotic expression were used to coat the microtiter plate. Values represent means ± SD of each group.
^aSignificant difference (p < 0.05), compared with the corresponding unexposed mice.
^bSignificant difference (p < 0.05), compared with the pre-exposed but unimmunized control.

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