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Figure 6 | Virology Journal

Figure 6

From: Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells

Figure 6

Schematic model of the process of viral cDNA integration in wt and LEDGF/p75-knockdown cells. (A) In LEDGF/p75-knockdown cells, an early expressed Rev (green triangle), from unintegrated viral DNA (brown double line), binds and inactivate all viral IN molecules (red circle) (in both the cytoplasm (light blue) and nucleus (yellow)) before integration occurs (due to the absence of LEDGF/p75 which supports rapid integration). (B) Addition of INS or INr peptides promotes dissociation of the inhibitory Rev-IN complexes, allowing the IN, which bound to viral DNA, to mediate integration into the host genome (black double line).

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