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Figure 6 | Virology Journal

Figure 6

From: Analysis of adenovirus trans-complementation-mediated gene expression controlled by melanoma-specific TETP promoter in vitro

Figure 6

Adenovirus co-replication enhancement of immune modulators CD40L and IL-2 expressed from CMV promoter cassette. Melanoma M000301 or colon SW480 cells were infected with AdCMV-CD40L (A, B), or AdCMV-IL-2 (C), at an MOI of 1.1, and were combined with 3-fold increasing amounts of RC wtAd5 and AdΔEP-TETP, or the replication-defective E1-deleted AdCMV-lacZ. The resulting ratios of RC/transgene vector are indicated. CD40L and IL-2 transgene expression analyses were performed two days p.i. by flow cytometry and ELISA, respectively. Asterisks indicate the level of significance (*P < 0.05; **P < 0.005; for comparison with corresponding wtAd5/AdCMV-CD40L values).

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Virology Journal

ISSN: 1743-422X