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Figure 1 | Virology Journal

Figure 1

From: Mutations at positions 186 and 194 in the HA gene of the 2009 H1N1 pandemic influenza virus improve replication in cell culture and eggs

Figure 1

Alignment of amino acid sequences of the S-OIV H1 HA with the H3 prototype HA in the region near the sialic acid binding site. Protein sequences translated from the deposited S-OIV A/CA/04/2009 sequence [GenBank: GQ117044] are shown under the prototype of the H3 subtype from human (A/HongKong/1/68) strain sequence [PDB: 1HGD]. Below these are the sequences detected in cDNA amplified from A/CA/04/2009 RNA, with the prominent quasispecies at positions 186 and 194 indicated by "X," and three plasmid DNAs cloned from this quasispecies. Underlining indicates variations from the posted sequence.

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