Prediction of prognostic biomarkers for Interferon-based therapy to Hepatitis C Virus patients: a metaanalysis of the NS5A protein in subtypes 1a, 1b, and 3a

Table 2 Summary comparison of the accuracy of different approaches used in the paper

*Method*	*Support*	*Confidence*
Site-specific class Association rules
Wildtype 2378T in NR subtype 1b	50%	69%
A2368T in R in subtype 1a	100%	52.2%
E2356G/D in R in subtype 1b	76.3%	67.3%
Number of variable sites Three variable sites in R	100%	25%
Six variable sites in R	1.7%	100%
Genetic distances GD > 0.2 for the V3 region in R	55%	35%
Profile Hidden Markov Model Score > 45 for R	70%	20%

The different methods studied applied to the V3 region, which has been shown in the paper to be the most important for response prediction are compared in this table. The positive predictive value of the methods on the test set are shown.

ISSN: 1743-422X