Prediction of prognostic biomarkers for Interferon-based therapy to Hepatitis C Virus patients: a metaanalysis of the NS5A protein in subtypes 1a, 1b, and 3a

Table 1 Summary of sequence analysis and mean genetic distance

*Region*	*Geno-type*	*Responder group*	*# of sequences*	*# of variable sites*	*Mean Genetic Distance within group*	*Mean genetic distance between groups*
NS5A	1a	R NR	21 42	21 31	0.017 0.02	0.03
NS5A	1b	R NR	20 42	34 25	0.017 0.02	0.029
NS5A	3a	R NR	17 10	24 21	0.045 0.036	0.041
ISDR	1a	R NR	21 42	3 3	0.04 0.032	0.4849
ISDR	1b	R NR	20 39	12 13	0.054 0.052	0.054
ISDR	3a	R NR	17 10	10 1	0.04 0.018	0.028
V3	1a	R NR	21 42	6 6	0.249 0.193	0.216
V3	1b	R NR	20 42	19 17	0.272 0.166	0.227
V3	3a	R NR	10 17	6 13	0.062 0.065	0.051

The number of sequences in each genotype and response group is shown; variable sites and mean genetic distance are calculated. The number of variable sites was extracted from the alignments, and mean genetic distances within and between groups were calculated using the MEGA program.

ISSN: 1743-422X