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Table 1 Replication of (recombinant) RSV in the upper and lower respiratory tract of cotton rats.

From: A highly attenuated recombinant human respiratory syncytial virus lacking the G protein induces long-lasting protection in cotton rats

Virusa

Day of harvestb

Lungs

Nose

  

% positive animalsc

Mean titer ± SD (log10TCID50/g)d

% positive animalsc

Mean titer ± SD (log10TCID50)d

RSV-A2

3

100

4.9 ± 0.3

100

3.0 ± 0.7

RSV-X

3

100

4.8 ± 0.3

100

3.7 ± 0.7

rRSV

3

50

2.8 ± 0.2

75

1.7 ± 0.3

ΔG

3

0

<2.1

0

<1.6

RSV-A2

5

100

5.1 ± 0.4

100

4.7 ± 0.2

RSV-X

5

100

4.7 ± 0.3

100

3.6 ± 0.5

rRSV

5

75

2.5 ± 0.2

100

2.2 ± 0.3

ΔG

5

0

<2.1

0

<1.6

RSV-A2

7

25

2.7

100

2.5 ± 0.8

RSV-X

7

0

<2.1

100

2.8 ± 0.9

rRSV

7

0

<2.1

ND

 

ΔG

7

0

<2.1

ND

 
  1. a Cotton rats were infected with 105 TCID50 (100 μl) of the indicated virus at day 0.
  2. b At the indicated days lungs and nasal washes were harvested and virus titers were determined.
  3. c Percentage of animals with detectable virus.
  4. d The lower limit of detection for virus in the lungs and nose was respectively 2.1 log10TCID50 g-1 and 1.6 log10TCID50. Groups consisted of 4 animals. ND: not determined.