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Figure 4 | Virology Journal

Figure 4

From: A highly attenuated recombinant human respiratory syncytial virus lacking the G protein induces long-lasting protection in cotton rats

Figure 4

Long term protection against RSV challenge lung histopathology in cotton rats. Cotton rats were immunized i.n. at day 0 with 105 TCID50 rRSV or ΔG. Challenge was performed at day 70 and 142 with 106 TCID50 RSV-X (i.n) and the animals were sacrificed 5 days later, at day 75 and 147, respectively. Groups consisted of 6 animals. Mean histopathological scores of following histopathological parameters: peribronchiolitis (black bars), hypertrophied mucous cells (brown bars), peribronchitis (white bars) and alveolitis (gray bars). Ctrl: control animals; mock: mock infected, challenged animals. *: statistically significant different (P < 0.05) compared to mock infected group based on the Wilxocon test.

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