From: Comparative whole genome sequence analysis of wild-type and cidofovir-resistant monkeypoxvirus
Protein | ORFa | Amino Acid | Domain | Δ Polarityb | Δ Hydropathyb | Surface Exposured | Surface Contoure |
---|---|---|---|---|---|---|---|
DNA pol | E9L | A314V | exonuclease | 0.1 | 2.4 | decrease | increase |
DNA pol | E9L | A613T | polymerase | 6.8 | 2.5 | increase | increase |
DNA pol | E9L | A684T | polymerase | 6.8 | 2.5 | increase | increase |
DNA pol | E9L | T808M | NA | 6.4 | 2.6 | decrease | decrease |
RNA pol subunit rpo147 | J6R | K355N | TFIIB docking | 5.3 | 3.12 | decrease | increase |
RNA pol subunit rpo147 | J6R | L653R | funnel | 22.3 | 8.3 | increase | increase |
mRNA capping enzyme small subunit | D12L | H122Y | dimerization | 4.2 | 1.9 | increase | decrease |
mRNA capping enzyme small subunit | D12L | S186N | dimerization | 4.6 | 2.7 | increase | decrease |
poly-A pol catalytic subunit VP55 | E1L | R342H | dimerization | 9.7 | 0.7 | decrease | decrease |