Figure 6

Topological feature maps of CDV-R (A) and WT (B) MPV DNA pol domain. type B DNA polymerase residues 525-806, T808M = T284,. Plotted residues 1-330 correspond to residues 525-806 in the MPV DNA pol catalytic domain. The A613T, A684T, and T808M substitutions (Table 1) correspond to positions 89, 160, and 284 in the plot. For comparison, regions of difference in secondary structure and biochemical characteristics between CDV-R and WT are designated by shaded areas in the vertical orange box.