Figure 4

Topological feature maps of CDV-R (A) and WT (B) MPV DNA pol 3'-5' exonuclease domain. Plotted residues 1-190 correspond to 162-351 in the MPV DNA pol exonuclease domain. The A314V substitution (Table 1) corresponds to position 153 in the plot. For comparison, regions of difference in secondary structure and biochemical characteristics between CDV-R and WT are designated by shaded areas in the vertical orange box.