Table 1 Cav-1 interactions with viral proteins

Retro

HIV-1

gp41

Transmembrane, fusion

Binding to CBD in HIV-1, but not HIV-2 or SIV

Binding to CSD*

(Benferhat et al., 2008; Hovanessian et al., 2004)

HIV-1

gp41

Transmembrane, fusion

Binding to six-helix bundle

Binding to CSD

(Huang et al., 2007)

HIV-1

Not known

Not known

Cav-1 membrane insertion domain

(Llano et al., 2002)

MLV-amphotropic, ecotropic

MA-Gag

Matrix, associates with membranes, link between capsid, plasma membrane, and viral membrane proteins

Binding mediated by a CBD in MA, interaction locates MA to lipid rafts domains in PM

Interaction with CSD*†

(Beer and Wirth, 2004; Yu et al., 2006)

Corona

SARS

ORF3a

Not known, Functioning in Golgi localization?

Binding to several CBDs

Not known, interaction with CSD likely

(Padhan et al., 2007)

Orthomyxo

Influenza A virus human

M2

Early phase: Ion channel, viroporin

Late Phase: matrix, virus assembly and budding

Binding. Protein regions presumably CBD aa47-55

Binding to CSD*†

Binding to CSD‡

This investigation

Zou et al. 2009

Influenza A virus human

HA

Receptor binding

Colocalization in perinuclear regions

(Scheiffele et al., 1998)

Paramyxo

RSV

?

?

Colocalization with internal viral filaments, colocalization at lipid rafts

Binding not specified, redistribution of Cav-1 after phosphorylation

(Brown et al., 2002; Brown, Rixon, and Sugrue, 2002; McDonald et al., 2004)

Reo

Rotavirus

NSP4

Ion channel formation, ER and caveolae localization, important for morphogenesis

Binding aa114-135 (enterotoxic peptide) amphipatic helix at the C-terminus

Binding and colocalization, 2 independent binding sites at the N-terminus (aa2-22)and C-terminus (aa161-178) identified, influence on localization or transport?

(Mir et al., 2007; Parr et al., 2006; Storey et al., 2007)