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Table 1 Cav-1 interactions with viral proteins

From: Caveolin-1 influences human influenza A virus (H1N1) multiplication in cell culture

Virus family
Virus Protein Protein function Type of interaction with protein partner Type of interaction with Cav-1 Reference
Retro HIV-1 gp41 Transmembrane, fusion Binding to CBD in HIV-1, but not HIV-2 or SIV Binding to CSD* (Benferhat et al., 2008; Hovanessian et al., 2004)
  HIV-1 gp41 Transmembrane, fusion Binding to six-helix bundle Binding to CSD (Huang et al., 2007)
  HIV-1 Not known   Not known Cav-1 membrane insertion domain (Llano et al., 2002)
  MLV-amphotropic, ecotropic MA-Gag Matrix, associates with membranes, link between capsid, plasma membrane, and viral membrane proteins Binding mediated by a CBD in MA, interaction locates MA to lipid rafts domains in PM Interaction with CSD*† (Beer and Wirth, 2004; Yu et al., 2006)
Corona SARS ORF3a Not known, Functioning in Golgi localization? Binding to several CBDs Not known, interaction with CSD likely (Padhan et al., 2007)
Orthomyxo Influenza A virus human M2 Early phase: Ion channel, viroporin
Late Phase: matrix, virus assembly and budding
Binding. Protein regions presumably CBD aa47-55 Binding to CSD*†
Binding to CSD‡
This investigation
Zou et al. 2009
  Influenza A virus human HA Receptor binding Colocalization in perinuclear regions (Scheiffele et al., 1998)
Paramyxo RSV ? ? Colocalization with internal viral filaments, colocalization at lipid rafts Binding not specified, redistribution of Cav-1 after phosphorylation (Brown et al., 2002; Brown, Rixon, and Sugrue, 2002; McDonald et al., 2004)
Reo Rotavirus NSP4 Ion channel formation, ER and caveolae localization, important for morphogenesis Binding aa114-135 (enterotoxic peptide) amphipatic helix at the C-terminus Binding and colocalization, 2 independent binding sites at the N-terminus (aa2-22)and C-terminus (aa161-178) identified, influence on localization or transport? (Mir et al., 2007; Parr et al., 2006; Storey et al., 2007)
  1. *Pull-down experiments with biotinylated CBD-peptides
  2. Co-immunoprecipitation
  3. ELISA