Figure 1From: Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase PSchematic representation of substrates for RNase P. (A) A natural substrate (ptRNA). (B) A hybridized complex of a target RNA (e.g., mRNA) and an EGS that resembles the structure of a tRNA. (C-F) Complexes between UL49 mRNA sequence and EGS324, C-EGS324, EGS1539, and C-EGS1539 respectively. The sequence of these EGSs equivalent to the tRNA sequence was derived from tRNASer and resembles the T-stem and loop, and variable region of the tRNA molecule.Back to article page