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Table 5 HPV status of the newborn and children and delivery factors.

From: Perinatal transmission of human papilomavirus DNA

Maternal variable

Newborn and children HPV-DNA

 

Positive

(n = 12)

Negative

(n = 37)

Type of HPV lesion

    

Genital warts

7

(58.3%)

21

(56.8%)

LGSIL1

2

(16.7%)

10

(27%)

HGSIL2

3

(25%)

6

(16.2%)

Site of HPV lesion

    

Uterine cervix

5

(41.7%)

16

(43.2%)

Vulva

4

(33.3%)

12

(32.4%)

Vulva + vagina

2

(16.7%)

5

(13.5%)

Vulva + perineal region

-

-

1

(2.7%)

Uterine cervix + vulva + vagina

1

(8.3%)

3

(8.2%)

Type of HPV Infection

    

Single

6

(50%)

13

(35.2%)

Double

1

(8.3%)

14

(37.8%)

Multiple

5

(41.7%)

10

(27%)

Type of delivery

    

Vaginal

5

(41.7%)

18

(48.6%)

Vaginal + forceps

-

-

1

(2.7%)

Cesarean section

7

(58.3%)

18

(48.6%)

Mean of the gestational age at delivery in the newborn HPV-DNA positive group (39.3 ± 0.9 weeks)

    

Mean of the gestational age at delivery in the newborn HPV-DNA negative group (39.3 ± 2.4 weeks)

    

Gestational age at the time HPV infection was diagnosed (weeks)

    

≥ 4 to ≤ 12

4

(33.3%)

15

(40.5%)

≥ 13 to ≤ 28

4

(33.3%)

8

(21.6%)

≥ 29 to ≤ 42

2

(16.7%)

6

(16.3%)

Prior to pregnancy

2

(16.7%)

8

(21.6%)

Mean in the newborn HPV-DNA positive group (14.6 ± 13.6 weeks)

    

Mean in the newborn HPV-DNA negative group (13.3 ± 12 weeks)

    

Time of RUPREME 3 (min)

    

≤ 360

12

(100%)

34

(91.9%)

≥ 361 to ≤ 720

-

-

1

(2.7%)

≥ 721

-

-

2

(5.4%)

Mean of newborn HPV-DNA positive group (39 ± 56 minutes)

-

-

-

-

Mean of newborn HPV-DNA negative group (103 ± 240 minutes)

-

-

-

-

Time of labor (min)

    

≤ 240

6

(50%)

22

(61.1%)

≥ 241 to ≤ 360

3

(25%)

9

(25%)

≥ 361

3

(25%)

6

(13.9%)

Mean of newborn HPV-DNA positive group (213 ± 225 minutes)

-

-

-

-

Mean of newborn HPV-DNA negative group (194 ± 196 minutes)

-

-

-

-

HPV lesion at delivery

    

Yes

7

(58.3%)

19

(51.4%)

No

5

(41.7%)

18

(48.6%)

  1. Data are reported as number and percentage (in parentheses) of newborn and children infection positive or negative for human papillomavirus. *P < 0.043 indicates a statistically significant difference between the positive and negative groups by Pearson's chi-square test. 1Low-grade squamous intraepithelial lesions. 2High-grade squamous intraepithelial lesions. 3RUPREME = rupture of amniotic membrane.