Skip to main content
Figure 5 | Virology Journal

Figure 5

From: Expression of Ebolavirus glycoprotein on the target cells enhances viral entry

Figure 5

A proposed model for EGP-mediated enhancement. Step 1. Receptor binding. EGP binds to its cell surface receptor(s). The bound virus is endocytosed into the cell, where it undergoes cleavage by cysteine proteases (cathepsin B and L) under low pH environment. Step 2. Fusion peptide insertion. The fusion peptide from the virion EGP is inserted into the host membrane. Also, EGP of the target cell inserts to the viral membrane through the fusion peptide. Step 3. Initiation of membrane fusion. Conformational changes occur on EGPs and lead to direct contact and interaction between the viral membrane-anchored EGP and the cell membrane-anchored EGP, forming an oligomeric complex. Membrane fusion ensues. Step 4. Membrane fusion. Fusion pore forms and host-viral contents mix.

Back to article page