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Table 1 HSV-1 in 1312-based recombinants used in the study1

From: Properties of virion transactivator proteins encoded by primate cytomegaloviruses

Mutant

Transgenes expressed2

in 1312

None

in 1374

HCMV IE-lacZ (UL43)

in 1316

YFPpp71 (TK)

in 1305

YFPS82 (TK)

in 1310

YFPpp71 (TK), HCMV IE-lacZ (UL43)

in 0150

YFPS82 (TK), HCMV IE-lacZ (UL43)

in 0144

YFPRh82 (TK), HCMV IE-lacZ (UL43)

in 0145

YFPB82 (TK), HCMV IE-lacZ (UL43)

in 0146

YFPCh82 (TK), HCMV IE-lacZ (UL43)

in 1357

SCMV IE-lacZ (TK)

in 1382

HCMV IE-lacZ (TK)

in 1383

HSV ICP0-lacZ (TK)

in 1372

HCMV IE-Cre (TK)

  1. 1. The parental mutant, in 1312, has mutations that inactivate the transcriptional activities of HSV-1 proteins VP16, ICP0 and ICP4. The construction of the mutants is described in materials and methods.
  2. 2. The insertion site in the in 1312 genome is shown in brackets.